Hello Maans,

You need to read the two Portugal travelogues we have on our web site!

We went to Setubal on our first visit. Yes, the bus drove all the way. It didn't go by ferry. According to the map I have, you'll have to go around the bay to get to Comporto. We didn't go there, we went from Setubal to Sesimbre, as you will read in our travelogue.

On our recent trip, we travelled along both sides of the Douro and we'd be hard-pressed to pick one over the other. But you also have other options to consider, such as the towns you'd like to visit along the way. You can cross back and forth, go high and low. Read our travelogues thoroughly and you'll get ideas about which routes might best suit your needs.

Regards, Don