I recommend staying near Piazza Navona. Yes, it is touristy, but that is because it is near many of the things tourists (aka travelers) want to see. It is well located to allow you to not walk long distances. This year, we stayed nearer to Termini, which was fine because we had no problem walking, but this fall we will be back for a few days and plan to stay near Piazza Navona.

Lisa in Chicago