Rather than drive in and out of TO with its delightful traffic snarls, I'm suggesting that you first try Burlington or Oakville.
>From Burlington I can even give you a route to downtown avoiding the QEW/403 combo if you let me know where you need to be!

I've included a site that lists most of the accommodations available in the area. The properties that have a website are a safe bet. So are the Admiral Inn, and the Quality Inn on Bronte Rd. Second choice -- rather than drive to and from Toronto, look into hotels/motels to the east of Hamilton.(Stoney Creek/Grimsby) You will find the drive much quicker and less stressful! I'll start researching that direction if it would help.

http://myburlington.com/tourism/accommodation.html

Anne Burlington ON