I go often to Seville and I always stay at the Hotel Becquer (a fourth star, classic style)

http://www.hotelbecquer.com

It is located near the Guadalquivir River, with parking.
>From this hotel you can walk to the center, is very easy and you don´t need public transportation or your rental car (I always walk).

Very near, in Paseo Cólon, you have a "tablao" very well known (touristy, of course.) and it is safe to walk at night from this hotel to the "tablao".

Enjoy your trip, Helena, from Lisbon